Since benzoic acid is part of the plant's natural defense against mold, yeast, and bacteria, it is commonly used as a preservative, especially in plant-based food, like juices. Benzoic acid, the simplest benzene-based carboxylic acid, has been known since the 16th century. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. Chemical foam. Hazard class: Specific target organ toxicity, single exposure; respiratory tract irritation . Slightly soluble in water. Quantitative structure-toxicity relationship (QSTR) studies play an important role in toxicity forecasting, which is widely used in the study of modern compounds. Effects of Benzoic Acid and Sodium Benzoate in chronic exposure animal studies were limited to reduced feed intake and reduced growth. Causes serious eye irritation (H319). However, even though it is not soluble in water, benzoic acid can be broken down by other solvents, such as alcohol. While no occupational exposure levels have been determined, benzoic acid may still constitute a health risk, thus it's important to constantly observe safe work practices: When these preservatives are added to foods . So what are the side effects of benzoic acid? BA interaction with CuONPs is shown to promote dissolved Cu release from CuONPs in a dose . But lab-synthesized sodium benzoate (and its close relative, benzoic acid) are a different story. After reviewing this study, the Expert Panel determined that the final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate should be reopened to The name is derived from gum benzoin, which was for a long time its only source. In a series of tests conducted by U.S. FDA, no effects were . LABORATORY USE. It is also found in several foods including grains, eggs, milk, and meat. Uses. Its most common natural source is gum benzoin, a resin found in the bark of trees of the genus Styrax. Both formulas contain the same . This leads to excretion of these amino acids and a decrease in ammonia levels. Inidviduals can react without having been previously exposed to benzoic acid. Therefore, its molecular formula is C 7 H 6 O 2 or C 6 H 5 COOH. Ingestion: Harmful if swallowed. I think the levels that would create a problem would be extraordinarily high, like concentrated benzoic acid. Benzoic acid is particularly hazardous to the environment because its decomposition can create toxic fumes and vapors; it can even become combustible and cause explosions under the right conditions. A molecular crystal rather than an ionic crystal, shown by its low melting point of 122 C, benzoic acid is used as an anti-microbial agent and is found in toothpastes, mouthwashes, cosmetics and deodorants. Skin and body protectionWear appropriate protective gloves and clothing to prevent skin . Do not eat, drink or smoke when using this product (P270). Benzoic acid itself has low toxicity, but there has been concern because of a potential reaction that converts it to benzene. It may also trigger food allergy symptoms in certain people, including rashes, itching and swelling. Benzoic acid is a good preservative on its own, . Synonyms . 60 toxicity potential of benzoic acid at doses up to 1000 mg/kg bw/day. Some differences between control and Benzyl Alcohol-treated populations were noted in one reproductive toxicity study using mice, but these were limited to lower maternal body weights and decreased mean litter . However, it would be difficult to consume so much of it in foods (both natural and processed) that it would be lethal.
For some, it may cause irritation and inflammation. There's nothing scary about the chemical in these items. Benzoic acid / bnzo.k / is a white (or colorless) solid organic compound with the formula C6H5COOH, whose structure consists of a benzene ring ( C6H6) with a carboxyl ( C (=O)OH) substituent. Acute inhalation toxicity Benzoic acid Rats : LC50 > 0.026 mg/l/h Ref. 122.13 Molecular Formula. Benzoic acid Revision Date 24-Dec-2021 Suitable Extinguishing MediaWater spray.Carbon dioxide (CO 2).Dry chemical. benzoic acid (pK. Updated. After reviewing this study, the Expert Panel determined that the final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate should be reopened to An excellent substance for showing this process is benzoic acid (C6H5COOH). Precautions to Take When Working with Benzoic Acid. Fire Hazard Behavior in Fire: Vapor from molten benzoic acid may form explosive mixture with air. The developmental toxicity of benzoic acid or sodium benzoate has been evaluated in several studies. : only cited in 45 2.3.4. The Bottom Line. Benzoic acid is a compound comprising a benzene ring core carrying a carboxylic acid substituent. If you experience these or any other adverse side effects, it's recommended to discontinue use and consult with your doctor. Benzilic acid is used in the manufacture of glycollate pharmaceuticals including clidinium, dilantin, flutropium, and mepenzolate which are antagonists of the muscarinic acetylcholine receptors.. Is benzoic acid hazardous? Repeated dose oral toxicity Sodium benzoate Groups of 6 male and 6 female Sherman rats were given 2 % (approx. Benzoic acid is non-toxic and stable under ordinary conditions. benzoic acid and sodium benzoate. Para-aminobenzoic acid (PABA) is a chemical that occurs naturally in the body. CHEM 2423 Recrystallization of Benzoic Acid Dr. Pahlavan 1 EXPERIMENT 4 - Purification - Recrystallization of Benzoic acid Purpose: a) To purify samples of organic compounds that are solids at room temperature . This was investigated under 61 more rigorous contemporary procedures using the Organisation for Economic Co-operation and Emits toxic vapors and gas including phenol, benzene, and carbon monoxide when heated to decomposition. The 24 h EC 50 values for monohalogenated benzoic acids in Daphnia ranged from 0.78 mmol l 1 for 3-bromobenzoic acid to 7.08 mmol l 1 for 4-fluorobenzoic acid. It has a role as an antimicrobial food preservative, an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, a plant metabolite, a human xenobiotic metabolite, an algal metabolite and a drug allergen.It is a conjugate acid of a benzoate. What is Benzilic acid used for? Benzoic Acid. Benzoic acid is non-toxic and stable under ordinary conditions. For this purpose we press the . Benzoic acid and salicylic acid may also be used for other purposes not listed in this . The Personal Care Products Council provided a 4-week inhalation toxicity study (rats) of aerosolized benzyl alcohol and benzoic acid. [ 6] Terrestrial toxicity Endpoint summary; Toxicity to soil macroorganisms except arthropods; Toxicity to terrestrial arthropods; Toxicity to terrestrial plants . Sodium benzoate is deemed safe, and people generally don't . Benzoic acid is an organic acid that is used as an antimicrobial agent, flavoring agent and preservative in its sodium salt form. benzoic acid. Related Pages. Irritation to the nose, throat and lungs if inhaled, which may cause coughing, wheezing and/or shortness of breath In addition to these short-term exposure effects, prolonged or repeated exposure to benzoic acid can cause drying and cracking of the skin with redness and itching. Impure benzoic acid contains the impurities phthalic acid and. Benzoic acid is relatively non-toxic and occurs naturally in plants. Terrestrial toxicity Endpoint summary; Toxicity to soil macroorganisms except arthropods; Toxicity to terrestrial arthropods; Toxicity to terrestrial plants . Of note, benzoic acid is very toxic to cats (they lack the ability to detoxify it in their livers) and can be lethal at doses of 0.5 g/kg of body weight ( 31 ).
Most benzoic acid produced today is synthetic. They concluded that it's safe to have benzoic acid in amounts of zero to 5 milligrams per kilogram (2.2 pounds) of body weight. Updated. 502016 BENZOIC ACID SAFETY DATA . Source: Benzoic Acid - Uses and Safety. Benzoic acid (BA) was administered in the diet to male and female Sprague Dawley Crl:CD(SD) rats in an OECD Test Guideline 443 Extended One-Generation Reproductive Toxicity (EOGRT) study to test . C 7 H 6 O 2. In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. Reports on fatal benzyl alcohol poisoning in premature neonates implied that the toxicity may be due to larger doses per kilogram than for adults. At elevated temperatures, fumes may cause irritation of eyes, respiratory system, and skin. Very toxic chemicals, or those that are reproductive hazards or sensitizers, require expert advice on control measures if a less toxic chemical cannot be substituted. 1 In 2001, the Cosmetic Ingredient Review (CIR) published a final report on the safety assessment of benzyl alcohol . 2-[3-Bromo-5-[[4-cyclopropyl-2-ethyl-5-(ethylcarbamoyl)imidazol-1-yl]methyl]-1-benzofuran-2-yl]benzoic acid | C27H26BrN3O4 | CID 9984662 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. The acute toxicity of benzoic acid and its salts is low (Rat,Oral LD50, 3040mg/kg bw). Benzoic acid and salicylic acid topical (for the skin) is a combination medicine used to treat skin irritation and inflammation caused by burns, insect bites, fungal infections, or eczema. Benzoic Acid 65-85- 100% Yes 3. Most of them may cause serious public health and environmental problems. In general, it is quite fine for plants. Hazardous Polymerization: Will not occur. It is slightly irritating to skin and the eye (IPCS,2000) In a study with volunteers given doses ranging from 1000-2500 mg/day for 5 days each, there were symptoms of toxicity including malaise, nausea, headache, weakness, burning and irritation of esophagus . Hazard class: Acute toxicity, oral (Category 4). 502016 BENZOIC ACID SAFETY DATA SHEET Version # 04 Revision Date: 07-06-2021 Print Date: 07-06-2021 Page 1 of 10 1. Benzoic acid safe dosage There is no defined "safe" level of benzoic acid or sodium benzoate. Benzoic acid is also not fat-soluble, so it will not concentrate in body fat. Benzoic acid increases the liver's workload, particularly if consumed with the amino acid glycine, found in protein-rich foods, dietary supplements, and antacids. benzoic acid and sodium benzoate. RTECS # DG0875000 CAS # 65-85- See: NMAM or OSHA Methods. Eye damage Skin irritation, causing rash, redness, and/or burning sensation Inhalation can irritate the nose, throat, and lungs and may cause coughing, wheezing, and/or shortness of breath In addition to these short-term exposure effects, prolonged or repeated exposure to benzoic acid can cause dry and cracked skin with redness and itching. March 2019 Molecular Weight. acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific . Benzoic Acid Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com SECTION 1 : Identification of the substance/mixture and of the supplier . Benzyl alcohol, benzoic acid and its salts (ie, sodium, calcium, magnesium, and potassium benzoate), and benzyl benzoate are reported to function as fragrance ingredients, pesticides, pH adjusters, preservatives, solvents, and/or viscosity decreasing agents in cosmetic products. Harmful if swallowed (H302). One of its discoverers was the legendary clairvoyant Nostradamus. KCL888 2 yr. ago Sources included: PABA is taken for a disease that causes . Human data on benzoic acid toxicity are available from early oral exposure studies conducted in human volunteers. Acute Toxicity Product Information Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Benzoic acid, 4-bromo- 1059 mg/kg (Mouse) Not listed Not listed OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. While occupational exposure limits have not been established, benzoic acid may still pose a health risk and, therefore, the safe work practices should always be followed: Wash hands thoroughly after handling. Overall, low exposure to benzoic acid appears to be non-toxic, but consuming a high amount may be poisonous. 2 Serious eye dam. Benzoic acid is currently manufactured from a petroleum byproduct called toluene. It is used to make other chemicals, in . : A63-500; A65-500; A68-30 . Acute exposure to benzoic acid or its sodium salt is associated with nonspecific signs and symptoms although metabolic acidosis has been implicated and daily intake of 4-6 g does not cause toxic symptoms aside from slight gastric irritation. The results of the available short-term and subchronic studies on benzoic acid and its salts indicated that their toxicity is low, with no marked target organ toxicity, although high intakes of benzoic acid may lead to disturbances in the acid/base balance, and benzoic acid at high doses may interfere with intermediary metabolism. Benzoic Acid is a white, crystalline (sand-like) powder with a faint, pleasant odor.
Benzoic acid is non-toxic and stable under ordinary conditions.While occupational exposure limits have not been established, benzoic . toxicity, and expense. While occupational exposure limits have not been established, benzoic acid may still pose a health risk and, therefore, the safe work practices should always be followed: Wash hands thoroughly after handling. Although benzene is a toxic and carcinogenic compound, the reaction causing this change has a very low chance of occurring in food. Studies have shown that benzoic acid in these individuals may cause gastrointestinal irritation, asthma attacks, rashes, itching, and irritation of the eyes and mucous membranes. Related Pages. Unsuitable Extinguishing MediaNo information available Flash Point 121 C / 249.8 F Method - No information available Autoignition Temperature 570 C / 1058 F Explosion Limits
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