Common side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or. A generic drug is an exact copy of the active drug in a brand-name medication. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. (A class of medications is a group of drugs that work in a similar way.) Increased liver enzymes can be a sign of liver damage. However, Zetia shouldnt be used with fibrate drugs other than fenofibrate. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. The heartbeat increases with a feeling of the heart fluttering. Lying down on the bed, and raising your legs. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . The generic form of Zetia costs about the same as the generic form of Crestor. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. 1. Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. Treatment is targeted at relieving low blood volume or regulating circulatory problems that may cause the disorder. (For more information, see Liver problems in the Warnings for Zetia section above.). People with this condition have high levels of LDL (bad) cholesterol, high levels of triglycerides, and low levels of HDL (good) cholesterol. If you would like to report to the FDA a side effect youve had with Zetia, you can do so through MedWatch. Zetia is metabolized in the small intestine and liver. For this purpose, Zetia may be used alone or with fenofibrate. This causes less cholesterol to travel from your small intestine to your liver. POTS is a kind of dysautonomia or autonomic nervous disorder. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. And your doctor can use this information to adjust your treatment plan if needed. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. Risk factors for muscle-related problems. Also, if you have a history of heavy drinking or liver damage, be sure to tell your doctor before you begin taking Zetia. Temporary excursions of 59F to 86F (15C to 30C) are allowed. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. Both Zetia and Crestor come as tablets that are swallowed. Brand-name medications usually cost more than generics. Porphyria patients are often overly sensitive to sunlight. Other interactions can increase side effects or make them more severe. During Zetia treatment, your doctor will likely recommend blood tests. If youre taking a statin drug with Zetia, they may recommend that you take a supplement called coenzyme Q10 (CoQ10). Or should I wait to see if I develop such side effects? For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. Zetia is meant to be used as a long-term treatment. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. What causes POTS? In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. If your doctor has prescribed Zetia and youre interested in using ezetimibe instead, talk with your doctor. They may be able to suggest ways to relieve this side effect. But its not clear whether this side effect occurred in studies. They may have suggestions depending on your weight and health goals. * For more information about this side effect, see " Zetia: Side effects explained " below. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Phase IV trials are used to detect adverse drug . If your doctor confirms you had a serious allergic reaction to Zetia, they may have you switch to a different treatment. Less commonly, taking Zetia may lead to serious side effects. Crestor contains the active drug rosuvastatin. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Lipitor, or with both drugs (when taken individually). Leqvio is a prescription drug used to lower cholesterol. Brand-name medications usually cost more than generics. Youll also need to check your insurance plan, as it may only cover one or the other. Cholesterol can also be found in foods such as eggs, cheese, and meat. The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . Use of the terms male and female in this article refers to sex assigned at birth. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. These side effects may be temporary, lasting a few days to weeks. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . The following information is provided for clinicians and other healthcare professionals. The expiration date helps guarantee that the medication is effective during this time. For more information about how the drug is used, see the Zetia uses section below. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. Zetias effect on cardiovascular morbidity and mortality isnt known. The effect of Zetia, atorvastatin, or simvastatin on other types of cholesterol levels in this study isnt known. Last medically reviewed on September 18, 2021. Once diagnosed, many patients face waiting lists as long as two years to get . If youre not sure if youll need to get prior authorization for Zetia, contact your insurance company. About Postural orthostatic tachycardia syndrome. Talk with your doctor if you experience diarrhea while taking this medication. Inability to speak. For more information, see the prescribing information for Zetia and Crestor. If youve noticed memory problems while taking Zetia, talk with your doctor. If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. During your Zetia treatment, consider keeping notes on any side effects youre having. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). An increase in these liver enzymes while using a statin drug can cause severe liver disease. Theyll likely suggest changes to your treatment plan. Zetia (ezetimibe) is a prescription drug that treats high cholesterol in adults and children. It belongs to a class of drugs called cholesterol absorption inhibitors. There arent any herbs or supplements that have been specifically reported to interact with Zetia. Cholesterol absorption inhibitors prevent your small intestine from absorbing cholesterol. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. More research is needed to know for sure. I am a stay at home mama to a sweet baby girl, and wife to an amazing h. Some side effects are more common than others. Zetia and Crestor have some similar side effects and others that differ. You may also be having a reaction to all the medications mixed together. Can diet help improve depression symptoms? The insurance company will review the prior authorization request and decide if the drug will be covered. Yes, treatment with Zetia should lower your triglycerides. (A class of drugs is a group of medications that work in a similar way.) For more information, see the How Zetia works section below. POTS is a form of orthostatic intolerance that is associated with the presence of excessive tachycardia and many other symptoms upon standing. Zetia is a brand-name drug that contains the active drug ezetimibe. Do my other medications increase my risk of side effects with Zetia? Zetia has been found in breast milk during animal studies. Zetia may stay in your system for several days after you stop taking it. Ezetimibe can cause the breakdown of muscle tissue . For instance, some interactions can interfere with how well a drug works. Nausea/Vomiting. Fatigue. Zetia side effects. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. Then you can share this information with your doctor. Zetia is FDA-approved to lower your total cholesterol level, and triglycerides are one part of your total cholesterol level. Drugs in this class prevent your small intestine from absorbing cholesterol. joint or muscle pain*. Serious side effects and their symptoms can include: * You may be more likely to experience this side effect if you take Zetia with a statin drug than if you take Zetia alone. You may wonder how Zetia compares with other medications that are prescribed for similar uses. We talked to experts about, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Also tell them about any vitamins, herbs, and supplements you use. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. Zetia is available as a tablet that you take by mouth. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. However, studies have found both Zetia and Lipitor to be effective for lowering cholesterol. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. If you have kidney problems, you may experience even higher levels of Zetia in your body. However, skip your missed dose if its almost time for your next dose. It is not yet clear what are the causes of POTS disease. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. Memory loss isnt a side effect of Zetia. For this purpose, Zetia may be used: The only FDA-approved dosage of Zetia is 10 mg once a day. No, clinical studies havent shown Zetia to affect blood pressure. What are the more common side effects of Zetia? Cholesterol is made naturally in your liver. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. The most common side effects of Zetia include: muscle or joint pain, * For these purposes, Zetia and Crestor are used to treat people of different ages. Cholesterol is a fatty substance found in the cells of your body. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. We avoid using tertiary references. Side effects of Lipitor and Zetia that are similar include diarrhea and joint pain. This section doesnt contain all drugs that may interact with Zetia. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. This makes it difficult to keep an upright posture without abnormal heart-rate (tachycardia) and/or sympathetic activity. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). For more information, see Liver problems in the Precautions section below. The brand name for this drug combination is Vytorin. Blood pressure medications and water pills (diuretics) All blood pressure medications can cause ED, but thiazide diuretics and beta blockers are the most likely to do so. Fenofibrate is a drug used to lower your triglyceride levels. They didnt take Zetia with other drugs that also treat high cholesterol. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). They may suggest foods that can help lower your cholesterol and reduce your risk of weight gain. For most people, CoQ10 isnt a harmful or dangerous supplement. Medications in this drug class prevent your liver from making new cholesterol. Zetia is a brand-name prescription drug. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. Dr. said Zetia was different and would not cause these side effects, so I agreed to try it. Zetia has a well-documented safety profile. Zetia is approvedto treat certain forms of high cholesterol in children ages 10 years and older. To reduce your symptoms in . Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. This included relief of muscle pain, muscle weakness, and cramps. Bock's fainting spells are one of the hallmarks of POTS. Phase IV trials are used to detect adverse drug . Statins are another type of medication used to lower cholesterol. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . What is considered high cholesterol? Study on Ezetimibe Yielded Disappointing Results: Another reader wrote us shortly after learning of the results of a study that raised questions about ezetimibe: Q. Your doctor will determine the best dosage to fit your needs. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. 2. Fenofibrate belongs to the fibrate drug class. Diarrhea is a common side effect of Zetia. Learn more about the link. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. Total cholesterol levels were reduced by an average of: LDL (bad) cholesterol levels were reduced by an average of: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. High cholesterol can raise your risk of heart disease. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. You cannot reliably predict how your body will react to a treatment based on someone elses experience. , you can not reliably predict how your body or dangerous supplement reduce levels. Clear whether this side effect be an increased risk of heart disease diet low in cholesterol saturated! Weight gain CoQ10 isnt a harmful or dangerous supplement inhibitors prevent your intestine. Effects or make what causes pots zetia more severe, some interactions can increase side effects youre having a medical.. 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